The Synthesis Of Most Coagulation Factors And Inhibitors

Liver has many haemostatic functions including the synthesis of most coagulation factors and inhibitors as well as fibrinolytic factors. The balance between procoagulant and anticoagulant factors is essential to prevent excessive blood loss from injured vessels and to prevent spontaneous thrombosis(11).The global effect of liver disease with regard to hemostasis is therefore complex, so that patients with advanced liver disease can experience severe bleeding or even thrombotic complications(12).In our study as regards presence of co- morbid factors namely DM and hypertension, the prevalence of DM and hypertension was higher in PVT group than non-PVT group, these results match the findings reported by Martinelli et al.(13) who clarified that hypertension and DM were associated with increased risk of PVT. That finding may be attributed to the association of dyslipidemia with diabetes and increased risk of atherosclerosis. So patients with liver cirrhosis and associated with diabetes or hypertension carry the risk for PVT more than cirrhotics without them. The number of patients who were Smokers and users ofISSN 2320-5407 International Journal of Advanced Research (2015), Volume 3, Issue 12, 1539 – 1548 1545 contraceptive pills were also statistically higher in PVT group than non-PVT group indicating that these may be factors for PVT development which goes in agreement with Shetty and Ghosh study (14). These results may be attributed to the hypercoagulability causedShow MoreRelatedSynthesis Of Most Coagulation Factors And Inhibitors2159 Words   |  9 PagesDiscussion: Liver has many haemostatic functions including the synthesis of most coagulation factors and inhibitors as well as fibrinolytic factors. 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